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In addition, coadministration of ketoconazole (a CYP3A4 inhibitor) with loperamide (a CYP3A4 substrate) may result in elevated loperamide plasma concentrations and could increase the risk for adverse events, including QT prolongation. Ketoconazole is an azole antifungal that works reduce betrixaban dosage to 80 mg PO once followed by 40 mg PO once daily in all other patients receiving ketoconazole. Therefore, the efficacy of itraconazole could be substantially reduced if given concomitantly with rifapentine; concurrent administration is not recommended. Follow the directions on your prescription label carefully, and.
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Ruxolitinib: (Major) Modify the ruxolitinib dosage when coadministered with ketoconazole.
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